Association between single nucleotide polymorphism (8q24.21) and lumbar degeneration disease in 800 cases from Guangxi Zhuang Autonomous Region

doi:10.3969/j.issn.2095-4344.1243

Abstract

Abstract:

BACKGROUND: A genome-wide association analysis performed on North European shows that single nucleotide polymorphism (8q24.21) is related to lumbar disc herniation, but the result in the other populations has not been confirmed.
OBJECTIVE: To investigate the association between single nucleotide polymorphism (8q24.21) and lumbar degenerative disease in Guangxi Zhuang population.
METHODS: Four hundred Zhuang populations with lumbar degenerative disease from January 2015 to December 2016 were selected as case group, and 400 healthy Zhuang adults as control group. The study was approved by the Ethics Committee of the First Affiliated Hospital of Guangxi Medical University. All participants were voluntary to the study and signed the informed consents. The case group was assigned into three subgroups based on MRI performance: lumbar disc herniation, lumbar spondylolisthesis, and lumbar spinal stenosis. The genomic DNA was extracted, and rs7816342 and rs4130415 (8q24.21) typing was detected by TaqMan prob. The distribution difference of allele frequency and genotype frequency was compared.
RESULTS AND CONCLUSION: (1) The allele frequency and genotype frequency of rs7816342 and rs4130415 (8q24.21) showed no significant difference between two groups (rs7816342, P=0.370; rs4130415, P=0.668). The genotype frequency of rs7816342 and rs4130415 was significantly different between lumbar spinal stenosis and control groups (rs7816342, P=0.008; rs4130415, P=0.006). (2) In summary, rs7816342 and rs4130415 polymorphism (8q24.21) is associated with lumbar spinal stenosis.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: 8q24.21 area, lumbar degenerative diseases, single nucleotide polymorphism, allele, genotype, genome-wide association analysis, Guangxi Zhuang Autonomous Region, Zhuang

CLC Number:

R446

Liu Yang, Yang Qinghua, Guan Yewen, Wang Jiaqi, Jiang Hua. Association between single nucleotide polymorphism (8q24.21) and lumbar degeneration disease in 800 cases from Guangxi Zhuang Autonomous Region [J]. Chinese Journal of Tissue Engineering Research, 2019, 23(19): 2980-2985.

Figures/Tables 3

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